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. 2015 Mar 18;17(1):64. doi: 10.1186/s13075-015-0587-4

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© Wang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Dose–response curve for HMGB1 in priming neutrophils and a representative histogram of effects of HMGB1 on translocation of PR3 over time. (A) was a representative histogram of effects of HMGB1 on translocation of PR3 over time. The levels of mPR3 expression on neutrophils (B) and MPO in the supernatant of neutrophils (C) was roughly dose-dependent. Bars represent mean ± standard deviation (SD) of repeated measurements of three independent experiments. HMGB1, high mobility group box-1; MPO, myeloperoxidase; PR3, proteinase 3.