Figure 6.

Cx43 and Panx1 hemichannel activity evoked by chronic stress on NMDA/P2X₇ receptor signaling. Averaged data normalized to maximal Etd uptake ratio (dashed line) obtained after chronic restraint stress in microglia (white bars), astrocytes (gray bars) and neurons (black bars) treated with the following blockers during the Etd uptake essay: CPP (20 µM), BBG (10 µM), oATP (200 µM), A740003 (10 µM), MRS2179 (10 µM) or CPP (20 µM) plus MRS2179 (10 µM). *p < 0.05, **p < 0.01; ***p < 0.001, effect of each blocker compared to the respective effect induced by chronic restraint stress. Averaged data were obtained from four independent experiments.