. 2015 Mar 20;6:6582. doi: 10.1038/ncomms7582

Table 1. pK_a* values for aqua adducts of catalysts 1–4 (and 8 for comparison) and turnover frequencies for transfer hydrogenation of NAD⁺ using formate.

Complexes		pK_a*	TOF (h⁻¹) D₂O/MeOH-d₄#	TOF (h⁻¹) D₂O
1	[(p-cym)Ru(MsEn)Cl]	9.86±0.01	1.25±0.03	1.11±0.02
2	[(p-cym)Ru(TsEn)Cl]	9.78±0.06	2.88±0.06	1.58±0.04
3	[(p-cym)Ru(TfEn)Cl]	9.71±0.01	5.7±0.3	3.06±0.05
4	[(p-cym)Ru(NO₂En)Cl]	9.56±0.04	9.6±0.3	4.1±0.1
8	[(bip)Ru(en)Cl]⁺	7.71±0.01†	—	—

pK_a*, pKa value determined in deuterated solvent; TOF, turnover frequency.

^#23% MeOH-d₄/77% D₂O.

^† ref. 31, pK_a value (pK_a* 7.85).

Table 1. pKa* values for aqua adducts of catalysts 1–4 (and 8 for comparison) and turnover frequencies for transfer hydrogenation of NAD+ using formate.