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. 2015 Mar 6;17(1):45. doi: 10.1186/s13075-015-0553-1

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© Blaschke et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Western blot analysis of responder and nonresponder sera. To validate results of serum proteome profiling, western blot analyses for haptoglobin (Hp)-α1, Hp-α2, apolipoprotein (Apo)C-III and ApoA-II were carried out. Serum samples from responders (n = 5) and nonresponders (n = 5) were subjected to western blot analysis with antibodies against the mentioned proteins. At baseline (V1), responder sera revealed a significant upregulation of Hp-α1 and Hp-α2 band intensities in comparison with nonresponders. These results were also detected after 6 months of etanercept treatment (V6). In contrast, the ApoC-III upregulation in responders could only be confirmed at baseline (V1). ApoA-II levels were found to be significantly upregulated in responders only after 3 months (V5) and 6 months (V6) of therapy in comparison with nonresponders.