Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 9;19(1):76. doi: 10.1186/s13054-015-0820-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Wang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Atenolol (ATE) inhibits cardiomyocyte apoptosis in lipolysaccharide (LPS)-challenged mice. Animals received intraperitoneal injection of normal saline or ATE (10 mg/kg) 1 hour before normal saline or 20 mg/kg LPS administration. At 12 hours after LPS administration, cardiomyocyte apoptosis was examined by TUNEL assay. (A) Representative photomicrographs of TUNEL assay (green) in the hearts from LPS and ATE plus LPS groups. Total nuclei were stained with DAPI (blue) and cardiomyocytes with anti-cTnI antibody (red). (B) Apoptotic index (AI) of cardiomyocytes (mean ± standard error of the mean (SEM); n = 8). (C) Cardiac caspase 3/7 activity at 6 hours after LPS administration (mean ± SEM; n = 8). ^* P <0.05 compared with the control group; ^# P <0.05 compared with the LPS group.