Table II.
Multivariate Cox proportional hazards model for 3-year mortality among elderly patients with diff use large B-cell lymphoma from 2000 to 2006 (n = 8262).
| Variable | Adjusted hazard ratio (95% CI) |
p-Value |
|---|---|---|
| Type of initial chemotherapy (reference = non-ACR-R) | ||
| ACR-R | 0.680 (0.598–0.773) | <0.0001 |
| ACR nR | 0.980 (0.838–1.145) | 0.7949 |
| R | 1.130 (0.938–1.361) | 0.1985 |
| Non-ACR nR | 2.052 (1.712–2.458) | <0.0001 |
| No systemic therapy | 3.055 (2.697–3.461) | <0.0001 |
| Age (reference = 66–70) | ||
| 71–75 | 1.228 (1.102–1.367) | 0.0002 |
| 76–80 | 1.593 (1.435–1.768) | <0.0001 |
| 81–84 | 1.777 (1.592–1.982) | <0.0001 |
| 85+ | 2.393 (2.146–2.668) | <0.0001 |
| Gender (reference = female) | ||
| Male | 1.054 (0.992–1.120) | 0.0885 |
| Race (reference = white) | ||
| Black | 1.010 (0.867–1.177) | 0.8974 |
| Other | 0.980 (0.861–1.116) | 0.7590 |
| Tumor stage (reference = stage I) | ||
| Stage II | 1.565 (1.423–1.720) | <0.0001 |
| Stage III | 1.930 (1.744–2.135) | <0.0001 |
| Stage IV | 2.473 (2.280–2.682) | <0.0001 |
| Unknown | 1.422 (1.245–1.625) | <0.0001 |
| Use of radiation in initial treatment (reference = no) | ||
| Yes | 0.681 (0.622 –0.745) | <0.0001 |
| Comorbidity (reference = no comorbidity) | ||
| Myocardial infarction (MI) | 1.130 (0.971–1.315) | 0.1132 |
| Chronic heart failure (CHF) | 1.276 (1.161–1.403) | <0.0001 |
| Peripheral vascular disease (PVD) | 1.057 (0.923–1.210) | 0.4213 |
| Cerebrovascular disease (CVD) | 1.114 (0.983–1.263) | 0.0897 |
| Chronic obstructive pulmonary disease (COPD) | 1.262 (1.154–1.381) | <0.0001 |
| Dementia | 1.608 (1.259–2.054) | 0.0001 |
| Paralysis | 1.039 (0.716–1.507) | 0.8404 |
| Diabetes | 1.205 (1.119–1.297) | <0.0001 |
| Chronic kidney disease (CKD) | 1.560 (1.350–1.802) | <0.0001 |
| Liver diseases* | 2.655 (1.882–3.746) | <0.0001 |
| Ulcers | 1.061 (0.876–1.285) | 0.5467 |
| Rheum disease | 1.092 (0.933–1.277) | 0.2723 |
| Acquired immunodeficiency syndrome (AIDS) | 1.089 (0.450–2.637) | 0.8493 |
| Year of diagnosis (reference = 2000) | ||
| 2001 | 1.029 (0.917–1.154) | 0.6316 |
| 2002 | 0.967 (0.859–1.089) | 0.5829 |
| 2003 | 0.954 (0.845–1.076) | 0.4428 |
| 2004 | 0.999 (0.885–1.127) | 0.9842 |
| 2005 | 0.909 (0.804–1.027) | 0.1253 |
| 2006 | 0.965 (0.853–1.091) | 0.5653 |
ACR, anthracycline-containing regimen; R, rituximab; CI, confidence interval.
*
Liver diseases: various cirrhodites or moderate–severe liver disease.