Table 4.
Interactions between TbHpHbR and HpSPHb
| Receptor | HpSPHb | ||||
|---|---|---|---|---|---|
| Residue | Group | Chain | Residue | Group | Interaction |
| Hbβ | |||||
| K56 | side chain | B | Haem144 | O1D | Hydrogen bond |
| E57 | side chain | B | K96 | Side chain | Salt bridge |
| S59 | side chain | B | Haem144 | O1D/O2D | Hydrogen bond |
| I60 | side chain | B | Patch | Hydrophobic | |
| R67 | side chain NH1 | B | R41 | Backbone CO | Hydrogen bond |
| E70 | side chain OE1/OE2 | B | R41 | Side chain NE/NH2 | Salt bridge |
| S161 | side chain | B | K60 | Side chain | Hydrogen bond |
| S161 | side chain | B | S45 | Backbone CO | Hydrogen bond |
| K164 | side chain | B | Haem144 | O2D | Hydrogen bond |
| R199 | side chain NE | B | Haem144 | O2A | Hydrogen bond |
| Y200 | side chain OH | B | Haem144 | O2A | Hydrogen bond |
| S203 | backbone CO | B | K96 | Side chain | Hydrogen bond |
| HpSP | |||||
| S73 | side chain | C | K345 | Side chain | Hydrogen bond |
| V74 | hydrophobic | C | Patch | Hydrophobic | |
| Q75 | OE1 | C | G276 | Backbone CO | Hydrogen bond |
| A78 | side chain | C | Patch | Hydrophobic | |
| A82 | side chain | C | Patch | Hydrophobic | |
| K85 | side chain | C | D305 | Side chain O2D | Salt bridge |