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. Author manuscript; available in PMC: 2015 Apr 2.
Published in final edited form as: J Autoimmun. 2009 Mar 16;33(1):42–49. doi: 10.1016/j.jaut.2009.02.003

Table 3.

Frequencies of B:9-23 and B:19A peptide-responsive hybridomas derived from mice with the transgenic TCR alpha chain paired with endogenous TCR β chains.

Insulin peptide response* 12-4.1 TCR α+Cα−/− Transgenic mice 12-4.4 TCR α+Cα−/− Retrogenic mice
positive 14/907
(1.54%)		 4/496
(0.8%)
negative 893/907
(98.46%)		 491/496
(99.2%)
*

Anti-insulin B:9-23 or B:19A peptide stimulation was evaluated with LacZ activity assay for all hybridomas. Both B:9-23 peptide responsive positive and non-responsive negative hybridomas responded to stimulation by anti-CD3 antibodies.