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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Exp Dermatol. 2014 Jun;23(6):407–413. doi: 10.1111/exd.12416

Figure 1.

Figure 1

AdWnt10b treatment enlarges hair follicle size without shifting its type. a. Schematic drawing showing the timing of multiple AdWnt10b injections, hair cycle events and check points. b-c. H&E staining and statistical chart showing that the width of HB, DP and HS was significantly increased after continuous AdWnt10b treatment. d-e. AE15 immunostaining and statistical chart revealed the IRS was broadened (Red line), and the hair fiber did not differentiate properly in the AdWnt10b-induced hair follicles (yellow arrow). f. About 65% of Zigzag hair follicles became enlarged, while only few Guard (G), Awl (A), Auchene (Au) hair follicles expanded in size. g. Wnt10b-induced larger Zigzag hair follicles were Sox2 negative while the normal Guard hairs were Sox2 positive. Epi, epidermis; SG, sebaceous gland; HFi, hair fiber; Bu, bulge; HB, hair bulb; HM, hair matrix; DP, dermal papilla; HS, hair shaft. *P < 0.05.