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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Exp Dermatol. 2014 Jun;23(6):407–413. doi: 10.1111/exd.12416

Figure 4.

Figure 4

DKK1 treatment decreased hair width. a. Schematic drawing showing the timing of DKK1 injection, hair follicle status and check points. b. DKK1 treatment narrowed the width of Zigzag, Auchene, and Awl hairs, and shortened the length of Awl hairs. c. Summary diagram showing that hair regeneration could be induced by ectopic WNT10b. Prolonged activation of Wnt signaling in the hair follicle would lead to greater interaction between the hair matrix epithelial cells and the DP mesenchymal cells, producing more proliferation and differentiation and broadening the HB, DP and HS. WNT10b could also promote migration of hair stem cells to sustain matrix proliferation. Interestingly, these processes can be rescued by giving DKK1 to inhibit regenerating hair follicles. Bu, bulge; DP, dermal papilla; HS, hair shaft.