Table 1. Somatic mutations in the MPNST discovery set.

Sample	NF1 germline mutation	NF1 somatic mutation	NF1 MAF (%)	SUZ12 somatic mutation	SUZ12 MAF (%)	Somatic deletions on chromosome 17	Other chromatin- modifying gene somatic mutations	Other driver gene mutations of interest
MPNST 01						NC_000017.10: g.26327000_33008000del
MPNST 02	NA						NM_003797.3 (EED):c.134delA	NM_000268.3 (NF2): c.552G>A
MPNST 04		NM_000267.3: c.7806+2T>C	85	NM_015355.2: c.252delG	100	NC_000017.10: g.57703000_8211000del
MPNST 05		NM_000267.3: c.5242C>T	88	NM_015355.2: c.1995_1996insC	79
MPNST 06a		NM_000267.3: c.6362delG	66	NM_015355.2: c.[333delG(;)334C>A]	100
MPNST 08	NA	NM_000267.3: c.6580–19delAGA GTATCCCCTTTTTTA	12				NM_001272004.1 (EPC1): c.330delT	NM_000489.4 (ATRX): c.1230delA
MPNST 09	NA						NM_001273.3 (CHD4): c.1358G>A
MPNST 10	NM_000267.3: c.2027_2028insC			NM_015355.2: c.1940delTAAT	23	NC_000017.10: g.25533000 30513000del

MAF, mutant allele fraction; NA, not applicable.

^aSections of this tumor were available for immunohistochemistry and were shown to be negative for staining with antibodies to both SUZ12 and H3K27me3.