Table 1.
Genes upregulated after exposure to different RNA or DNA viruses.
| Gene name† | Virus‡ | |||||
|---|---|---|---|---|---|---|
| LASV | YF17D | Dengue | Hantavirus | Ebola | Vaccinia | |
| DDX58 (RIG-1) | ✓ | ✓ | ✓ | ✓ | ||
| DHX58 | ✓ | ✓ | ||||
| DSPTI1 | ✓ | ✓ | ✓ | |||
| EIF2AK2 | ✓ | ✓ | ✓ | |||
| EPSTI1 | ✓ | ✓ | ||||
| GBP1 | ✓ | ✓ | ✓ | ✓ | ||
| HERC5 | ✓ | ✓ | ✓ | ✓ | ||
| HERC6 | ✓ | ✓ | ✓ | ✓ | ||
| IFIH1 | ✓ | ✓ | ||||
| IFI6 | ✓ | ✓ | ✓ | ✓ | ||
| IFI44 | ✓ | ✓ | ✓ | ✓ | ✓ | |
| IFI44L | ✓ | ✓ | ✓ | |||
| IFIT1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| IFIT2 | ✓ | ✓ | ✓ | |||
| IFIT3 | ✓ | ✓ | ✓ | ✓ | ||
| IFIT5 | ✓ | ✓ | ||||
| IFI35 | ✓ | ✓ | ||||
| IFIH1 (MDA-5) | ✓ | ✓ | ✓ | ✓ | ||
| IFITM1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| IFITM3 | ✓ | ✓ | ||||
| IL-1a | ✓ | ✓ | ✓ | ✓ | ||
| IRF7 | ✓ | ✓ | ✓ | ✓ | ✓ | |
| ISG15 | ✓ | ✓ | ✓ | ✓ | ||
| ISG20 | ✓ | ✓ | ✓ | |||
| LY6E | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| MMP1 | ✓ | ✓ | ||||
| MX1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| MX2 | ✓ | ✓ | ✓ | ✓ | ✓ | |
| OAS1 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| OAS2 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| OAS3 | ✓ | ✓ | ✓ | ✓ | ||
| OASL | ✓ | ✓ | ✓ | |||
| PARP12 | ✓ | ✓ | ✓ | |||
| PLAU | ✓ | ✓ | ||||
| PNPT-1 | ✓ | ✓ | ||||
| RSAD2 | ✓ | ✓ | ✓ | |||
| SP110 | ✓ | ✓ | ✓ | |||
| SCG5 | ✓ | ✓ | ||||
| STAT1 | ✓ | ✓ | ✓ | ✓ | ||
| THBM | ✓ | ✓ | ✓ | |||
| TRIM5 | ✓ | ✓ | ||||
| TRIM22 | ✓ | ✓ | ✓ | ✓ | ||
| TNFS10 | ✓ | ✓ | ✓ | |||
| XAF-1 | ✓ | ✓ | ✓ | |||
†
These are names of commonly upregulated genes after a cell is exposed to a virus. Most of these genes are ‘IFN-stimulated genes’ or ISGs.
‡
The viruses are LASV [124,127], the vaccine strain Yellow Fever-17D (YF17D) [123,128,129], Dengue virus [130,131], Hantavirus [132], Ebola virus [133,134] and a vaccine strain of poxvirus, Vaccinia [129].
LASV: Lassa virus.