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Extracellular signal-regulated kinase or activation of protein kinase B inhibition abrogates protective effect of renalase peptide. Wild-type mice subjected to sham surgery or to 30 min of renal ischemia and reperfusion; RP-H220 or vehicle (saline) injected 10 min before renal ischemia. Extracellular signal-regulated kinase inhibitor PD98059 or the PI3K or activation of protein kinase B inhibitor wortmannin abrogated RP-H220’s protective effect.
