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Renalase and α-NAD(P)H oxidase/anomerase: proposed scheme. Oxidation of α-dihydropyridyl ring of NAD(P), with transfer of two electrons to the flavin cofactor of renalase, and conversion of the ribose C1 from α to β configuration; reduced FAD cofactor is reoxidized by reacting with dioxygen-yielding hydrogen peroxide as a reaction byproduct.
