Table 1. Characteristics of the study group stratified on the basis of gender (G) and incidence of diabetes (D).
| Diabetes | Females | Males | P value | |
|---|---|---|---|---|
| Age (years) | no | 68 (44–76, 14) | 70 (55–78, 11) | G: 0.44 |
| yes | 64 (51–78, 6) | 67 (59–70, 4) | D:0.30 | |
| GxD:0.91 | ||||
| BMI (kg/m2) | no | 34 (26–42, 14) | 28 (24–35, 11) | G: 0.066 |
| yes | 36 (29–40, 6) | 36 (33–39, 4) | D:0.002 | |
| GxD:0.064 | ||||
| Serum leptin | no | 45 (16–85, 14) | 9.3 (4.3–18, 9) | G: 0.0002 |
| yes | 36 (14–56, 6) | 28 (16–32, 3) | D:0.43 | |
| GxD:0.0095 | ||||
| CSF leptin | no | 290 (180–440, 14) | 140 (42–190, 9) | G: 0.0005 |
| yes | 240 (190–390, 6) | 210 (110–220, 3) | D:0.87 | |
| GxD:0.18 | ||||
| Serum AEA | no | 0.26 (0.11–0.54, 14) | 0.21 (0.11–0.33, 11) | G: 0.082 |
| yes | 0.28 (0.13–0.31, 5) | 0.15 (0.092–0.15, 4) | D:0.41 | |
| GxD:0.59 | ||||
| Serum 2-AG | no | 3.4 (0.91–6.1, 14) | 3.5 (0.96–5.0, 11) | G: 0.23 |
| yes | 3.3 (0.67–5.5, 6) | 1.4 (0.86–2.9, 4) | D:0.23 | |
| GxD:0.31 | ||||
| CSF AEA | no | 14 (6–22, 14) | 17 (4–30, 11) | G: 0.96 |
| yes | 11 (8–25, 5) | 10 (6–21, 4) | D:0.38 | |
| GxD:0.33 | ||||
| CSF 2-AG | no | 64 (30–220, 13) | 99 (14–170, 11) | G: 0.45 |
| yes | 99 (0–180, 5) | 100 (75–120, 4) | D:0.84 | |
| GxD:0.76 |
Data are given as medians with ranges, followed by the sample sizes in parentheses. Serum leptin levels are given as ng/ml while CSF leptin levels are given as pg/ml; serum AEA and 2-AG levels are given as ng/ml; and CSF AEA and 2-AG levels are given as pg/ml. P values are calculated using a non-parametric two-way robust Wilcoxon analysis [38]. Significant correlations are shown in boldface.