Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram of Cl− secretion stimulated by TRPA1 in colonic epithelial cells. Activation of apical TRPA1 by luminal AITC causes prostaglandins synthesis. The synthesized PGE2 may then be released basolaterally. This released PGE2 may act on EP4 receptors. Activation of the EP4 receptor induces an increase in [cAMP]i which then activates the CFTR Cl− channels to induce Cl−/HCO3 − secretion.
