Table 2.
Incidence of treatment-related adverse events.
| AE, N | Number of subjects | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 56 mg/m2 (n = 3) | 74 mg/m2 (n = 14) | 98 mg/m2 (n = 4) | Total (n = 21) | |||||||||
| G1 | G2 | ≥G3 | G1 | G2 | ≥G3 | G1 | G2 | ≥G3 | G1 | G2 | ≥G3 | |
| Hepatotoxicity | ||||||||||||
| AST | — | — | — | 1 | — | — | — | — | — | 1 (5%) | — | — |
| ALT | — | 1 | — | — | — | — | — | — | — | — | 1 (5%) | — |
| GGT | — | 1 | — | — | 1 | — | — | 1 | — | — | 3 (14%) | — |
| TG | — | — | — | 1 | — | — | — | — | — | 1 (5%) | — | — |
| Abdominal distention | 1 | — | — | 1 | — | — | — | — | — | 2 (10%) | — | — |
| Pruritus | — | — | — | 1 | — | — | — | — | — | 1 (5%) | — | — |
| Arthralgia | — | — | — | 1 | — | — | — | — | — | 1 (5%) | — | — |
| Low-grade fever | 3 | — | — | — | — | — | — | — | — | 3 (14%) | — | — |
| Hypokalemia | — | — | — | 1 | — | — | — | — | — | 1 (5%) | — | — |
G1, G2, and G3 represent grade 1, grade 2, and grade 3, respectively, according to NCI-CTC grades.
AE: adverse event; —: no occurrence.