Table 3.
Parameter | Unit | Day 1 | Day 14 |
---|---|---|---|
Mean ± SD | Mean ± SD | ||
t 1/2 | h | 4.58 ± 2.04 | 4.00 ± 1.27 |
V d | L/m2 | 88.60 ± 31.80 | 89.90 ± 28.10 |
CL | L/(h·m2) | 14.40 ± 3.94 | 15.80 ± 3.05 |
AUC(0–t) | ng·h/mL | 5172 ± 1136 | 4705 ± 873 |
AUC(0–∞) | ng·h/mL | 5498 ± 1525 | 4834 ± 933 |
MRT(0–t) | h | 3.34 ± 0.55 | 3.30 ± 0.31 |
MRT(0–∞) | h | 4.31 ± 1.89 | 3.78 ± 0.70 |
T max | h | 3.00 ± 1.41 | 3.63 ± 1.06 |
C max | ng/mL | 1589 ± 635 | 1211 ± 204 |