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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Brain Imaging Behav. 2015 Mar;9(1):128–140. doi: 10.1007/s11682-015-9363-y

Figure 1. Effects of the ERBB4 variation on cortical structures.

Figure 1

(a) Statistical maps for the effects of the ERBB4 on cortical thickness, area, and volume at each vertex were generated using the general additive model. Sex, GAF, SES and scanner device were included as covariates, and the models were corrected for multiple comparisons with the false discovery rate (FDR; 0.05). The effects of the ERBB4 genotype on cortical structures were plotted against age. (b) Children with the TT-risk genotype for schizophrenia/bipolar disorder (red) showed a more pronounced inverted U-shaped age-trajectory compared to the non-risk genotype children (CC in green and CT in blue) in cortical areas of the left inferior parietal cortex (shown left, b), left temporal lobe (c) and right posterolateral temporal lobule (f), as well as in volumes of the left anteromedial temporal cortex (d), and in volumes of the left temporal lobe (e).

The anteromedial temporal (AMT) region comprises the fusiform, entorhinal and parahippocampal cortices.