Table 3.
Average daily drug dose and percentage on titrated doses for diabetes agents and statins by sex.
| Agent | N | Average daily dose (mg) | % on titrated dose | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Female | Male | Female | Male | P value | Threshold | Female | Male | P value | |
| Taking diabetes drug | 622 | 1465 | — | — | — | Diabetes drugs | 72% | 73% | 0.63 |
| Any insulin sensitizing | 394 | 1015 | — | — | — | IS | 58% | 62% | 0.27 |
| TZD | 111 | 322 | — | — | — | TZD | 46% | 42% | 0.46 |
| Pioglitazone | 61 | 139 | 32.5 | 31.3 | 0.49 | >30 mg | 36% | 32% | 0.54 |
| Rosiglitazone | 50 | 183 | 6.7 | 6.0 | 0.12 | >4 mg | 58% | 50% | 0.30 |
| Metformin | 344 | 907 | 1517.5 | 1526.2 | 0.83 | >1000 mg | 58% | 61% | 0.31 |
| Any insulin providing | 515 | 1162 | — | — | — | IP | 71% | 69% | 0.34 |
| Sulfonylurea | 316 | 864 | — | — | — | SU | 63% | 64% | 0.66 |
| Glyburide | 192 | 540 | 18.0 | 13.5 | 0.30 | >5 mg | 75% | 73% | 0.58 |
| Glipizide | 87 | 236 | 17.6 | 14.0 | 0.31 | >10 mg | 31% | 44% | 0.03 |
| Glimepiride | 37 | 88 | 5.1 | 4.3 | 0.17 | >2 mg | 76% | 66% | 0.28 |
| Insulin | 249 | 397 | 0.7 unit/kg | 0.6 unit/kg | 0.17 | >0.4 unit/kg | 75% | 68% | 0.04 |
| Taking statin | 483 | 1186 | — | — | — | Statins | 46% | 46% | 0.96 |
| Atorvastatin | 181 | 443 | 29.4 | 25.0 | 0.01 | >10 mg | 66% | 62% | 0.36 |
| Lovastatin | 16 | 42 | 28.8 | 35.5 | 0.18 | >20 mg | 38% | 64% | 0.07 |
| Pravastatin | 41 | 92 | 32.9 | 24.8 | 0.002 | >40 mg | 5% | 1% | 0.17 |
| Simvastatin | 245 | 609 | 28.8 | 29.8 | 0.53 | >20 mg | 39% | 41% | 0.71 |
IS = insulin sensitizing; IP = insulin providing diabetes drugs; SU = sulfonylurea.