Table 3. Comparison of 5 and 10 year outcomes for usual care vs. genomics-based care decisions using individual level probabilities.

	Usual Care Treatment	GC-Based Treatment	P values
Mayo Clinic Cohort
5 year BCR free survival probability	0.632 (0.623, 0.642)	0.707 (0.698, 0.716)	< 0.001
10 year BCR free survival probability	0.425 (0.416, 0.435)	0.496 (0.486, 0.505)	< 0.001
5 year MET or Death probability	0.135 (0.128, 0.142)	0.129 (0.122, 0.135)	0.115
10 year MET or Death probability	0.324 (0.315, 0.333)	0.307 (0.298, 0.316)	< 0.001
TJU Cohort
5 year BCR free survival probability	0.624 (0.615, 0.633)	0.705 (0.696, 0.714)	< 0.001
10 year BCR free survival probability	0.415 (0.406, 0.425)	0.495 (0.485, 0.505)	< 0.001
5 year MET or Death probability	0.110 (0.104, 0.117)	0.106 (0.100, 0.112)	0.007
10 year MET or Death probability	0.276 (0.267, 0.285)	0.261 (0.252, 0.269)	< 0.001

Results are presented for the Mayo Clinic and TJU cohorts. McNemar’s test was used to test for significant differences between usual care and GC-based treatment outcomes for each cohort.

BCR = biochemical recurrence; MET = metastasis; GC = genomic classifier.