Table 1. MHC (RT1) immunogenetics of strain combinations used for heart transplantation to BMT recipients.
strain combinations | MHC gene region | |||
---|---|---|---|---|
RT1A class I | RT1B/Dclass II | RT1C/Eclass I | ||
recipient | LEW.1AR2 | a | a | u |
BM donor | LEW.1AR1 | a | u | u |
heart donor | LEW.1WR1 | u | u | a |
Heart graft donor strain (LEW.1WR1) shares the u haplotype in the RT1B/D region with BMC donor strain (LEW.1AR1). It is disparate to BMC donor strain in the MHC class I encoding regions RT1A and RT1C/E. To the recipient strain (LEW1AR2) it is disparate in all MHC antigen complex encoding regions.