Table 1.
Probe set–identified transcripts up-regulated by ≥ 2-fold in response to 24‑hr arsenite exposure.
| Sequence code | Accession no.a | Sequence | Description | Arsenite/vehicle control | |
|---|---|---|---|---|---|
| Fold change time 0 | ANOVA p-value time 0 | ||||
| 203665_at | NM_002133 | HMOX1 | Heme oxygenase (decycling) 1 | 68.36 | 1.45 × 10–13 |
| 209699_x_at | U05598 | AKR1C2 | Aldo-keto reductase family 1, member C2 | 15.74 | 2.92 × 10–11 |
| 204151_x_at | NM_001353 | AKR1C1 | Aldo-keto reductase family 1, member C1 | 11.99 | 1.45 × 10–13 |
| 207528_s_at | NM_014331 | SLC7A11 | Solute carrier family 7, member 11 | 7.42 | 1.45 × 10–13 |
| 241418_at | AI819386 | LOC344887 | 7.30 | 1.45 × 10–13 | |
| 213112_s_at | N30649 | SQSTM1 | UPF0544 protein | 6.85 | 1.45 × 10–13 |
| 206561_s_at | NM_020299 | AKR1B10 | Aldo-keto reductase family 1, member B10 | 5.92 | 5.61 × 10–9 |
| 207469_s_at | NM_003662 | PIR | Pirin (iron-binding nuclear protein) | 5.39 | 1.45 × 10–13 |
| 234986_at | AA630626 | GCLM | Glutamate-cysteine ligase, modifier subunit | 5.19 | 1.45 × 10–13 |
| 219926_at | NM_022361 | POPDC3 | Popeye domain containing 3 | 4.71 | 1.71 × 10–8 |
| 204341_at | NM_006470 | TRIM16 | Tripartite motif-containing 16 | 3.51 | 4.86 × 10–12 |
| 211071_s_at | BC006471 | MLLT11 | Myeloid/lymphoid or mixed-lineage leukemia | 3.36 | 2.21 × 10–10 |
| 221064_s_at | NM_023076 | UNKL | Unkempt homolog-like | 3.34 | 1 × 10–5 |
| 219902_at | NM_017614 | BHMT2 | Betaine-homocysteine methyltransferase 2 | 3.25 | 1.45 × 10–13 |
| 225252_at | AL121758 | SRXN1 | Sulfiredoxin 1 homolog | 3.12 | 1.45 × 10–13 |
| 201468_s_at | NM_000903 | NQO1 | NAD(P)H dehydrogenase, quinone 1 | 2.95 | 1.45 × 10–13 |
| 228580_at | AI828007 | HTRA3 | Serine protease HTRA3 isoform X1 | 2.92 | 1.45 × 10–13 |
| 224461_s_at | BC006121 | MGC13000 | Apoptosis-inducing factor 2 | 2.92 | 4.05 × 10–9 |
| 218416_s_at | AW149696 | SLC48A1 | Solute carrier family 48 (heme) | 2.90 | 2.7 × 10–6 |
| 219475_at | NM_013370 | OSGIN1 | Oxidative stress induced growth inhibitor 1 | 2.86 | 3 × 10–5 |
| 207850_at | NM_002090 | CXCL3 | Chemokine (C-X-C motif) ligand 3 | 2.78 | 7.4 × 10–4 |
| 208161_s_at | NM_020037 | ABCC3 | Canalicular multispecific organic anion transporter 2 isoform 1 | 2.76 | 4.54 × 10–3 |
| 212314_at | AB018289 | KIAA0746 | KIAA0746 protein | 2.75 | 1.55 × 10–12 |
| 214211_at | AA083483 | FTH1 | Ferritin heavy chain | 2.71 | 1.45 × 10–13 |
| 205633_s_at | NM_000688 | ALAS1 | Aminolevulinate, delta-, synthase 1 | 2.68 | 1.45 × 10–13 |
| 235548_at | BG326592 | APCDD1L | Adenomatosis polyposis coli down-regulated 1-like | 2.50 | 5 × 10–5 |
| 239067_s_at | AI360417 | PANX2 | Pannexin 2 | 2.47 | 1.7 × 10–3 |
| 209875_s_at | M83248 | SPP1 | Secreted phosphoprotein 1 | 2.44 | 4.86 × 10–11 |
| 207180_s_at | NM_006410 | HTATIP2 | HIV-1 Tat interactive protein 2, 30 kDa | 2.41 | 1.45 × 10–13 |
| 205608_s_at | U83508 | ANGPT1 | Angiopoietin 1 | 2.39 | 4.9 × 10–4 |
| 202017_at | NM_000120 | EPHX1 | Epoxide hydrolase 1, microsomal | 2.30 | 9.25 × 10–11 |
| 203192_at | NM_005689 | ABCB6 | ATP-binding cassette, sub-family B, member 6 | 2.24 | 4.1 × 10–4 |
| 201118_at | NM_002631 | PGD | Phosphogluconate dehydrogenase | 2.21 | 1.45 × 10–13 |
| 228955_at | AL041761 | 2.18 | 6.14 × 10–8 | ||
| 204059_s_at | NM_002395 | ME1 | Malic enzyme 1, NADP(+)-dependent, cytosolic | 2.18 | 1.45 × 10–13 |
| 202275_at | NM_000402 | G6PD | Glucose-6-phosphate dehydrogenase | 2.09 | 3.96 × 10–13 |
| 1563884_at | AK074255 | 2.05 | 6.6 × 10–3 | ||
| 228205_at | AU152969 | TKT | Transketolase, transcript variant X1 | 2.04 | 1.7 × 10–4 |
| 228937_at | AI659800 | C13orf31 | 2.03 | 2.73 × 10–10 | |
| 217359_s_at | M22094 | NCAM1 | Neural cell adhesion molecule 1 | 2.00 | 5.17 × 10–3 |
| Blanks under “Sequence” and “Description” indicate that no gene name or function has been ascribed to those transcripts. Many of the transcripts represented here were identified by multiple probe sets, but only one probe set–identified transcript is shown for each gene. aGenBank accession numbers (http://www.ncbi.nlm.nih.gov/genbank/). | |||||