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. 2015 Apr 2;10(4):e0122900. doi: 10.1371/journal.pone.0122900

Table 1. Histological scores of severity for livers collected 64 days after irradiation from 12 Gy-irradiated rats with hind limbs or head protection treated with Enrofloxacin and control rats treated or not with Enrofloxacin.

Parameters C C + E 12 Gy HL-p + E 12 Gy H-p + E
Hepatocytes 1,67 2 2.67 2.33
Hepatocyte rows 0 0 0.67 1.67
Steatosis 0 0 0 0
Sinusoids 0.67 0.67 0.33 1.33
Fibrosis 0 0 0 0.67
Macrophages 0.67 0 1 1
Lymphocytes 1 1 1 1
Necrosis 0 0 1 1.33
Global Histological Score 4 ±0.58 3.67 ±0.33 6.67 ±0.33 ( * ) 9.33 ±0.88 ( *** , § )

Rat Groups: C: Control; C + E: Control + Enrofloxacin; 12 Gy HL-p + E: 12 Gy Hind limbs-protected + Enrofloxacin; 12 Gy H-p + E: 12 Gy Head-protected + Enrofloxacin. For each parameter and for each rat group, values represent the average of scores obtained in three animals. Global histological scores represent average values (± SEM) of cumulated histological scores obtained from three rats for each group

* (p<0.05);

*** (p<0.001): significant versus control + Enrofloxacin;

§ (p<0.05): significant versus 12 Gy hind limbs-protected + Enrofloxacin).