Table 1. Histological scores of severity for livers collected 64 days after irradiation from 12 Gy-irradiated rats with hind limbs or head protection treated with Enrofloxacin and control rats treated or not with Enrofloxacin.
Parameters | C | C + E | 12 Gy HL-p + E | 12 Gy H-p + E |
---|---|---|---|---|
Hepatocytes | 1,67 | 2 | 2.67 | 2.33 |
Hepatocyte rows | 0 | 0 | 0.67 | 1.67 |
Steatosis | 0 | 0 | 0 | 0 |
Sinusoids | 0.67 | 0.67 | 0.33 | 1.33 |
Fibrosis | 0 | 0 | 0 | 0.67 |
Macrophages | 0.67 | 0 | 1 | 1 |
Lymphocytes | 1 | 1 | 1 | 1 |
Necrosis | 0 | 0 | 1 | 1.33 |
Global Histological Score | 4 ±0.58 | 3.67 ±0.33 | 6.67 ±0.33 ( * ) | 9.33 ±0.88 ( *** , § ) |
Rat Groups: C: Control; C + E: Control + Enrofloxacin; 12 Gy HL-p + E: 12 Gy Hind limbs-protected + Enrofloxacin; 12 Gy H-p + E: 12 Gy Head-protected + Enrofloxacin. For each parameter and for each rat group, values represent the average of scores obtained in three animals. Global histological scores represent average values (± SEM) of cumulated histological scores obtained from three rats for each group
* (p<0.05);
*** (p<0.001): significant versus control + Enrofloxacin;
§ (p<0.05): significant versus 12 Gy hind limbs-protected + Enrofloxacin).