Table 2. Histological scores of severity for kidneys collected 64 days after irradiation from 12 Gy-irradiated rats with hind limbs or head protection treated with Enrofloxacin and control rats treated or not with Enrofloxacin.
Parameters | C | C + E | 12 Gy HL-p + E | 12 Gy H-p + E |
---|---|---|---|---|
Glomeruli | 0 | 0 | 1 | 1.67 |
Tubular structure | 0 | 0.33 | 1.33 | 2.67 |
Epithelial cells | 0.33 | 0.33 | 1.67 | 2.67 |
Fibrin deposition | 0.33 | 0.67 | 1 | 1 |
Vascular dilation | 0.67 | 0 | 1 | 1.33 |
Inflammatory cells | 0.33 | 0 | 1 | 1.33 |
Fibrosis | 0 | 0 | 0 | 0.33 |
Necrosis | 1 | 0.33 | 1 | 2 |
Medulla | 0 | 0 | 0 | 1 |
Global Histological Score | 2.67 ±0.33 | 1.67 ±0.88 | 8 ±0.58 ( ** ) | 14 ±1.73 ( *** , §§ ) |
Rat Groups: C: Control; C + E: Control + Enrofloxacin; 12 Gy HL-p + E: 12 Gy Hind limbs-protected + Enrofloxacin; 12 Gy H-p + E: 12 Gy Head-protected + Enrofloxacin. For each parameter and for each rat group, values represent the average of scores obtained in three animals. Global histological scores represent average values (± SEM) of cumulated histological scores obtained from three rats for each group
** (p<0.01);
*** (p<0.001): significant versus control + Enrofloxacin;
§§ (p<0.01): significant versus 12 Gy Hind limbs-protected + Enrofloxacin).