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. 2015 Apr 2;10(4):e0122900. doi: 10.1371/journal.pone.0122900

Table 2. Histological scores of severity for kidneys collected 64 days after irradiation from 12 Gy-irradiated rats with hind limbs or head protection treated with Enrofloxacin and control rats treated or not with Enrofloxacin.

Parameters C C + E 12 Gy HL-p + E 12 Gy H-p + E
Glomeruli 0 0 1 1.67
Tubular structure 0 0.33 1.33 2.67
Epithelial cells 0.33 0.33 1.67 2.67
Fibrin deposition 0.33 0.67 1 1
Vascular dilation 0.67 0 1 1.33
Inflammatory cells 0.33 0 1 1.33
Fibrosis 0 0 0 0.33
Necrosis 1 0.33 1 2
Medulla 0 0 0 1
Global Histological Score 2.67 ±0.33 1.67 ±0.88 8 ±0.58 ( ** ) 14 ±1.73 ( *** , §§ )

Rat Groups: C: Control; C + E: Control + Enrofloxacin; 12 Gy HL-p + E: 12 Gy Hind limbs-protected + Enrofloxacin; 12 Gy H-p + E: 12 Gy Head-protected + Enrofloxacin. For each parameter and for each rat group, values represent the average of scores obtained in three animals. Global histological scores represent average values (± SEM) of cumulated histological scores obtained from three rats for each group

** (p<0.01);

*** (p<0.001): significant versus control + Enrofloxacin;

§§ (p<0.01): significant versus 12 Gy Hind limbs-protected + Enrofloxacin).