Table 2.
Functional annotation analysis of genes harboring candidate defects in two subgroups of index cases
| Annotation term | P valuea | No. of genes |
|---|---|---|
| Gi signaling abnormality | ||
| Intracellular signaling | 3.8 × 10−3 | 13 |
| Secretion abnormality | ||
| Establishment of protein localization | 3.2 × 10−4 | 13 |
| Protein transport | 5.9 × 10−4 | 13 |
| Protein localization | 4.1 × 10−4 | 13 |
| Vesicle‐mediated transport | 8.3 × 10−4 | 11 |
a
Terms are sorted based on the Benjamini‐corrected Modified Fisher Exact P‐value as reported in DAVID (http://david.abcc.ncifcrf.gov). P < 0.05 denotes significance.