. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2015 Jan 22;24(4):677–682. doi: 10.1158/1055-9965.EPI-14-1224

Table 1.

Mean, median, and variance of PCA3, and sensitivity and specificity of various PCA3 and PSA cutoffs in the EDRN data and the simulated populations (validation and projected). The simulated values for PCA3 are derived from the exponential distributions matching the observed PCA3 medians.

		EDRN Data	Simulated Populations
PCA3 Mean	Noncancer	29.3	25.6
PCA3 Mean	Cancer	68.7	71.8

PCA3 Median	Noncancer	17.8	17.8
PCA3 Median	Cancer	49.8	49.8

PCA3 Standard	Noncancer	1869.8	655.8
Deviation	Cancer	4487.0	5161.9

Sensitivity	PCA3>20	0.78	0.76
	PCA3>35	0.62	0.61
	PCA3>60	0.42	0.43
	PSA(4)+PCA3(0)^*	0.79	0.81
	PSA(4)+PCA3(20)^*	0.63	0.60
	PSA(4,10)+PCA3(20,0)^*	0.66	0.65

Specificity	PCA3>20	0.56	0.54
	PCA3>35	0.77	0.75
	PCA3>60	0.89	0.90
	PSA(4)+PCA3(0)^*	0.28	0.29
	PSA(4)+PCA3(20)^*	0.68	0.67
	PSA(4,10)+PCA3(20,0)^*	0.64	0.59

Numbers in “Simulated Population” column refer to validation population only. See methods section for key to nomenclature.