Table 3.

Screening and prostate cancer (PC) mortality outcomes in the projected population (N=10,000) when PCA3 varies by grade, for select strategies from Table 2. Grade-specific sensitivities refer to the PCA3 test properties alone. Grade is either low grade (LG) or moderate to high-grade (M-HG).

Strategy	LG Median PCA3	M-HG Median PCA3	LG Sensitivity of PCA3	M-HG Sensitivity of PCA3	LG Cases Detected	M-HG Cases Detected	Over-diagnoses	PC Deaths	Lives Saved
PSA(4)+PCA3(20)	50	50	0.758	0.758	531	389	291	223	130
	30	85	0.630	0.850	443	437	272	223	130
	20	103	0.500	0.874	353	449	241	228	125
PSA(4)+ PCA3(35)	50	50	0.616	0.616	431	316	237	247	105
	30	85	0.445	0.752	312	386	211	246	107
	20	103	0.297	0.790	211	406	178	250	103