Table 2.
Multivariate Analysis
| Covariate | Overall Survival | Relapse Free Survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate HR | p-value | Multivariate HR | p-value | Univariate HR | p-value | Multivariate HR | p-value | |
| DNMT3A mut and stnd dose (vs. DNMT3A wt or DNMT3A mut and high dose) | 1.71 | 0.014 | 1.90 | 0.006 | 1.47 | 0.070 | 1.69 | 0.017 |
| DNMT3A mut (vs. DNMT3A wt) | 1.21 | 0.331 | ------ | ------ | 1.02 | 0.911 | ------ | ------ |
| High dose (vs. stnd dose) | 0.83 | 0.355 | ------ | ------ | 0.83 | 0.339 | ------ | ------ |
| Age ≥60 (vs. Age <60) | 2.16 | <0.001 | 2.62 | <0.001 | 2.25 | <0.001 | 2.10 | <0.001 |
| Intermediate Cytogenetics (vs. Favorable) | 2.59 | 0.016 | 2.71 | 0.016 | 1.27 | 0.388 | 1.37 | 0.317 |
| Poor Cytogenetics (vs. Favorable) | 3.29 | 0.006 | 2.66 | 1.10 | 1.68 | 0.096 | 1.19 | 0.616 |
| Unknown Cytogenetics (vs. Favorable) | 2.55 | 0.0800 | 3.62 | 0.022 | 1.42 | 0.391 | 1.68 | 0.268 |
| Female sex (vs. Male sex) | 0.92 | 0.645 | ------ | ------ | 0.93 | 0.656 | ------ | ------ |
| FLT3-ITD (vs. no FLT3-ITD) | 1.45 | 0.068 | 1.87 | 0.006 | 1.15 | 0.455 | 1.56 | 0.037 |
| NPM1 mut (vs. NPM1 wt) | 0.84 | 0.390 | 0.50 | 0.002 | 0.79 | 0.174 | 0.55 | 0.005 |
| IDH1 mutated (vs. IDH1 wt) | 0.91 | 0.792 | ------ | ------ | 0.75 | 0.375 | ------ | ------ |
| IDH2 mutated (vs. IDH2 wt) | 0.93 | 0.782 | ------ | ------ | 0.87 | 0.585 | ------ | ------ |
| Allo tx (vs. no allo-tx) | 0.46 | <0.001 | ------ | ------ | 0.73 | 0.072 | ------ | ------ |
Abbreviations: mut, mutant; vs, versus; wt, wildtype; stnd, standard; Allo tx, Allogeneic transplant; HR, hazard ratio