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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Cancer Res. 2015 Feb 24;75(7):1399–1412. doi: 10.1158/0008-5472.CAN-14-2785

Figure 7. Stratification of human melanomas by sensitivity to PDK1 inhibition.

Figure 7

(A) The mean IC50 for GSK2334470 inhibition of growth of 19 human melanoma cell lines was used to segregate cell lines into sensitivity or resistance to the inhibitor. (B) Heat map of the results of the IPA analysis showing the genes/pathways most significantly altered (P < 0.05; fold change >1.5) by GSK2334470 (1178 differentially expressed genes). (C) qPCR analysis of Dct, Tyr, and Il6 mRNA in YUMM1.5 cells treated with DMSO or GSK2334470 at 5 μM for 24 h (Dct and Tyr) or at 10 μM for 6 h (Il6). Values are the mean ± SEM of biological triplicates. *P < 0.05, **P < 0.01.