Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Cancer Res. 2015 Feb 17;75(7):1388–1398. doi: 10.1158/0008-5472.CAN-14-2561

Figure 5. ω-3 PUFAs induce 15-PGDH and inhibit cholangiocarcinoma growth in vivo.

Figure 5

CCLP1 cells (with Fat-1 overexpression, miR26a overexpression, Fat-1/miR26a co-expression, or control vector cells) were inoculated into SCID mice (n=6). Tumors growth was monitored and recovered 35 days later. Overexpression of Fat-1 inhibited tumor growth in vivo; this effect was reversed by overexpression of miR26a. Overexpression miR26a alone was found to enhance tumor growth in vivo. (A) Gross photograph of tumors recovered from SCID mice. (B) Bar graphs showing the average volume of recovered tumors and the average miR26a expression levels in the recovered tumors. The volume of tumor was calculated as described in the methods; the level of miR26a was measured by real-time PCR. Results were normalized to control group. Data was presented as mean mean±SE, *P<0.05, **P<0.01; (C) Representative Western blot for 15-PGDH in recovered tumor tissues. β-actin was measured as a reference gene.