Table 1.

Distributions of cigarette smoking, hormone therapy and folate intake by ESR2 tumor expression among incident CRC cases.

Attribute*	ESR2 Negative N=66	ESR2 Low N=126	ESR2 High N=299	Overall N=491
Age at Baseline: mean (SD)	63.8 (4.3)	63.0 (3.8)	62.9 (4.1)	63.1 (4.1)
Age at CRC Diagnosis: mean (SD)	73.6 (6.3)	73.9 (5.9)	73.9 (5.9)	73.9 (5.9)
Smoking Status
Never	47 (71.2%)	77 (61.6%)	191 (65%)	315 (64.9%)
Ever	19 (28.8%)	48 (38.4%)	103 (35%)	170 (35.1%)
Former	14 (21.2%)	29 (23.2%)	59 (20.1%)	102 (21%)
Current	5 (7.6%)	19 (15.2%)	44 (15%)	68 (14%)
Average Number of Cigarettes per Day
0	47 (72.3%)	77 (61.6%)	191 (65.2%)	315 (65.2%)
1–19	10 (15.4%)	23 (18.4%)	49 (16.7%)	82 (17%)
20–39	7 (10.8%)	19 (15.2%)	45 (15.4%)	71 (14.7%)
≥ 40	1 (1.5%)	6 (4.8%)	8 (2.7%)	15 (3.1%)
Cumulative Pack-Years Cigarettes Smoked
0	47 (72.3%)	77 (62.6%)	191 (65.9%)	315 (65.9%)
1–19	10 (15.4%)	16 (13%)	36 (12.4%)	62 (13%)
20–39	3 (4.6%)	15 (12.2%)	35 (12.1%)	53 (11.1%)
≥ 40	5 (7.7%)	15 (12.2%)	28 (9.7%)	48 (10%)
Hormone Therapy
Never	41 (62.1%)	87 (70.2%)	196 (66.7%)	324 (66.9%)
Ever	25 (37.9%)	37 (29.8%)	98 (33.3%)	160 (33.1%)
Former	21 (31.8%)	27 (21.8%)	67 (22.8%)	115 (23.8%)
Current	4 (6.1%)	10 (8.1%)	31 (10.5%)	45 (9.3%)
Duration of Hormone Therapy
Never	41 (62.1%)	87 (70.7%)	196 (67.1%)	324 (67.4%)
≤ 5 Years	21 (31.8%)	26 (21.1%)	68 (23.3%)	115 (23.9%)
> 5 Years	4 (6.1%)	10 (8.1%)	28 (9.6%)	42 (8.7%)
Folate Intake (µg/d)
≤ 250	16 (25.8%)	23 (20%)	70 (25.8%)	109 (24.3%)
251–350	17 (27.4%)	35 (30.4%)	82 (30.3%)	134 (29.9%)
351–573	14 (22.6%)	21 (18.3%)	66 (24.4%)	101 (22.5%)
≥ 574	15 (24.2%)	36 (31.3%)	53 (19.6%)	104 (23.2%)

^*Numbers may not sum to totals due to missing data.