Table 5.

Appearance of first antibody in seropositive RA cases where both antibodies of interest were present in prediagnosis serum.

Comparing anti-CCP2 to anti-CarP-FCS		Mean Years of anti-CCP2	p*
Anti-CCP2 preceded Anti-CarP-FCS	4/16 cases	Preceding anti-CarP-FCS
Anti-CarP-FCS preceded Anti-CCP2	0/16 cases	0.76	0.13
First appearance in same sample	12/16 cases
Comparing anti-CCP2 to anti-CarP-Fib		Mean Years of anti-CCP2	p*
Anti-CCP2 preceded Anti-CarP-Fib	4/12 cases	Preceding anti-CarP-Fib
Anti-CarP-Fib preceded Anti-CCP2	0/12 cases	1.01	0.13
First appearance in same the sample	8/12 cases
Comparing RF-Neph to anti-CarP-FCS		Mean Years of anti-CarP-FCS	p*
RF-Neph preceded Anti-CarP-FCS	2/16 cases	Preceding RF-Neph
Anti-CarP-FCS preceded RF-Neph	3/16 cases	0.08	0.81
First appearance in the same sample	11/16 cases
Comparing RF-Neph to anti-CarP-Fib		Mean Years of anti-CarP-Fib	p*
RF-Neph preceded Anti-CarP-Fib	2/7 cases	Preceding RF-Neph
Anti-CarP-Fib preceded RF-Neph	1/7 cases	0.01	1.00
First appearance in the same sample	4/7 cases

^*p-value for signed rank test