Skip to main content
. Author manuscript; available in PMC: 2016 Apr 6.
Published in final edited form as: J Proteomics. 2014 Oct 2;118:81–94. doi: 10.1016/j.jprot.2014.09.011

Figure 6.

Figure 6

Analysis of mediator by BioID and AP-MS reveals distinct interactome profiles for MED4, MED20 and MED23. (A) Hierarchical clustering (Pearson correlation, complete linkage clustering) of SAINTexpress output from AP-MS and BioID data obtained for MED4, MED20 and MED23. (B) Highlight of the mediator complex (box #1) observed following SAINTexpress analysis. Mediator complex subunits were colored as per legend. Highlighted box #2 is associated with Figure 7A. Please note that bait proteins are not displayed in the heat map presented in panel A and B. (C) Summary of the overlap between the interaction partners of the three mediator subunits studied by BioID and AP-MS, excluding mediator subunits themselves.