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. 2015 Apr 3;3:7. doi: 10.1186/s40345-014-0018-5

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© Wu et al.; licensee Springer. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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RAD design. At the beginning (stage 1), there are 365 patients in total. Eighty-five patients take Bupropion, 93 patients take Paroxetine, and 187 patients take placebo. After 6 weeks, 104 patients’ information are lost. Only 78 patients are tracked with non-response at the end of stage 1. At stage 2, patients with non-response are assigned to secondary treatment intervention. Patients taking Bupropion or Paroxetine at stage 1 will increase current doses. But patients taking placebo at stage 1 will be assigned Bupropion or Paroxetine.