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Schematic representation of patients in the study cohort based on severity of AA, presence of PNH clone, and presence of somatic mutations with or without transformation to MDS. The detailed data on PIGA mutations are provided in the supplemental Data. Only patients in the first cohort (n = 57) were screened for PIGA mutations, and 23 of 57 patients had a PNH clone detected by flow cytometry.
