Table 1.
General Characteristics in LETO and OLETF Rats fed AD or CR at 8 and 40 weeks of age
| LETO (8 weeks) | OLETF (8 weeks) | LETO (40 weeks) | OLETF (40 weeks) | |||||
|---|---|---|---|---|---|---|---|---|
| AL (n = 6) | CR (n = 6) | AL (n = 6) | CR (n = 6) | AL (n = 6) | CR (n = 6) | AL (n = 6) | CR (n = 6) | |
| Body Wt. (g) | 245 ± 12 | 239 ± 11 | 246 ± 11 | 249 ± 16 | 445 ± 2 | 395 ± 25a | 608 ± 31a | 549 ± 29ab |
| sBP (mmHg) | 126 ± 7.1 | 124 ± 5.4 | 121 ± 5.6 | 124 ± 5.8 | 130 ± 6.5 | 129 ± 5.6 | 148 ± 7.1a | 134 ± 5.1b |
| Heart wt. (g) | – | – | – | – | 1.24 ± 0.06 | 1.30 ± 0.07 | 1.41 ± 0.07 | 1.32 ± 0.08 |
| H/B wt. ratio | – | – | – | – | 2.39 ± 0.07 | 2.11 ± 0.10b | 2.41 ± 0.10 | 2.41 ± 0.18 |
| Glucose | 98 ± 4.8 | 111 ± 7.1 | 141 ± 8.2a | 138 ± 6.9a | 108 ± 6.8 | 116 ± 5.8 | 178 ± 7.3a | 139 ± 7.1b |
| Serum Insulin | 2.2 ± 0.1 | 2.4 ± 0.1 | 7.6 ± 0.32a | 8.1 ± 0.38a | 2.3 ± 0.1 | 2.0 ± 0.1b | 10.3 ± 0.5a | 4.6 ± 0.4ab |
| HOMA-IR | 0.52 ± 0.03 | 0.66 ± 0.05 | 2.64 ± 0.11a | 2.74 ± 0.18a | 0.61 ± 0.04 | 0.57 ± 0.04 | 4.53 ± 0.23a | 1.58 ± 0.06ab |
| Total Cholesterol | 108 ± 6 | 110 ± 5 | 121 ± 9a | 126 ± 7a | 111 ± 7 | 106 ± 6 | 158 ± 1a | 129 ± 6b |
| Triglyceride | 41 ± 2 | 45 ± 3 | 42 ± 2 | 38 ± 3 | 164 ± 10a | 128 ± 5ab | 241 ± 15a | 153 ± 9ab |
| Adiponecin | 2.1 ± 0.1 | 2.2 ± 0.1 | 1.8 ± 0.1 | 1.9 ± 0.1 | 1.9 ± 0.1 | 2.7 ± 0.1ab | 1.5 ± 0.1a | 3.2 ± 0.2ab |
Values are mean ± SE
AL ad libitum; CR calorie restriction; sBP systolic blood pressure; H/B wt. ratio heart to body weight ratio (mg/g); HOMA-IR homeostasis model of assessment—insulin resistance, glucose; Total cholesterol and Triglyceride mg/dl; Insulin μU/ml; Adiponectin μg/ml
a p < 0.05 versus 8 weeks old same strain rats fed AL
b p < 0.05 versus 40 weeks old same strain rats fed AL