Table 2.
Results of doppler echocardiography in LETO and OLETF Rats with AL or CR at 8 and 40 weeks of age
| LETO (8 weeks) | OLETF (8 weeks) | LETO (40 weeks) | OLETF (40 weeks) | |||||
|---|---|---|---|---|---|---|---|---|
| AL (n = 6) | CR (n = 6) | AL (n = 6) | CR (n = 6) | AL (n = 6) | CR (n = 6) | AL (n = 6) | CR (n = 6) | |
| HR (beats/min) | 388 ± 18 | 394 ± 19 | 402 ± 21 | 392 ± 23 | 441 ± 19 | 428 ± 20 | 435 ± 21 | 418 ± 18 |
| LVEDD (mm) | 6.3 ± 0.3 | 6.2 ± 0.5 | 6.9 ± 0.5 | 6.7 ± 0.4 | 8.1 ± 0.4 | 7.9 ± 0.4 | 8.3 ± 0.5 | 7.9 ± 0.4 |
| LVESD (mm) | 3.9 ± 0.3 | 3.8 ± 0.2 | 4.2 ± 0.2 | 4.0 ± 0.2 | 4.6 ± 0.3 | 4.5 ± 0.3 | 4.7 ± 0.2 | 4.6 ± 0.3 |
| FS (%) | 39 ± 1.8 | 38 ± 1.7 | 39 ± 2.1 | 40 ± 2.4 | 43 ± 2.9 | 43 ± 2.4 | 43 ± 2.1 | 42 ± 2.4 |
| E (cm/sec) | 103 ± 8.7 | 104 ± 6.8 | 105 ± 5.9 | 101 ± 6.2 | 106 ± 6.3 | 107 ± 5.9 | 98 ± 5.4a | 101 ± 7.1ab |
| A (cm/sec) | 41 ± 2.8 | 42 ± 2.7 | 43 ± 1.8 | 41 ± 2.2 | 42 ± 2.6 | 44 ± 2.8 | 46 ± 2.1a | 44 ± 2.9b |
| E/A | 2.5 ± 0.18 | 2.4 ± 0.17 | 2.4 ± 0.16 | 2.4 ± 0.16 | 2.5 ± 0.15 | 2.4 ± 0.15 | 2.1 ± 0.15a | 2.3 ± 0.18b |
| E′ (cm/sec) | 10.1 ± 0.6 | 9.8 ± 0.5 | 10.3 ± 0.7 | 9.7 ± 0.5 | 9.7 ± 0.4 | 9.8 ± 0.6 | 12.5 ± 0.7a | 10.6 ± 0.5ab |
| E/E′ ratio | 10.4 ± 0.71 | 10.6 ± 0.60 | 10.2 ± 0.55 | 10.4 ± 0.66 | 10.9 ± 0.53 | 10.9 ± 0.56 | 7.8 ± 0.42a | 9.5 ± 0.38ab |
| DT (m sec) | 34 ± 1.2 | 35 ± 1.7 | 33 ± 1.7 | 34 ± 1.4 | 40.0 ± 2.2 | 39.4 ± 2.5 | 47.8 ± 2.8a | 42.2 ± 2.9ab |
Values are mean ± SE
HR heart rate; LVEDD left ventricular end-diastolic dimension; LVESD left ventricular end-systolic dimension; FS fractional shortening, FS was determined by the following equation: FS = [(LVEDD−LVESD)/LVEDD] × 100 (%); E/A ratio peak velocity of early transmitral inflow (E)-to-peak velocity of late transmitral inflow (A) ratio; E’ early mitral annulus velocity; DTE decelaration time of the E wave
a p < 0.05 versus LETO rats fed AL
b p < 0/05 versus OLETF rats fed AL