Table 3.

The impact of acute and chronic administration of salsolinol on the l-DOPA-induced increase in the concentration of 3-MDOPA in the rat striatum

Treatment	3-MDOPA (ng/g tissue)
Saline	1.31 ± 0.11
Salsolinol 100 acute	1.46 ± 0.1
Salsolinol 100 chronic	1.39 ± 0.11
l-DOPA 100	17,429 ± 2874**
Salsolinol 100 acute + l-DOPA 100	16,046 ± 1770**
Salsolinol 100 chronic + l-DOPA 100	15,102 ± 3278**
Effect of treatment	F (5/40) = 15.22 P < 0.01

Salsolinol was administered (100 mg/kg i.p.) acutely or chronically for 14 consecutive days. In the combined treatment group, l-DOPA (100 mg/kg i.p.) was administered once 15 min after the final salsolinol administration. The rats were decapitated 2 h after the final injection. The concentration of 3MDOPA was measured using HPLC. The results are expressed as the means  ±  SEM of six to ten samples. The data were analyzed via one-way ANOVA followed by Duncan’s test. Statistical significance: * P < 0.05, ** P < 0.01 versus the control group; ⁺ P < 0.05, ⁺⁺ P < 0.01 versus the l-DOPA group