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. 2015 Mar;12(1):41–45. doi: 10.7497/j.issn.2095-3941.2014.0024

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Copyright: © 2015, Cancer Biology & Medicine

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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(A) Diffuse involvement of bone marrow by HL with the identification of Reed-Sternberg cells (arrows) in an appropriate background (H&E, ×10); (B) Diffuse bone marrow fibrosis observed with methenamine-silver stain (×100); (C) Focal pattern of BM involvement in HL with the presence of a large binucleated Reed-Sternberg cell (arrow) (H&E, ×100); (D) Immunohistochemistry show some CD15⁺ Reed-Sternberg cells (IHC,×40); (E) Immunohistochemistry with expression of CD30 antigen in an adequate cellular background by Reed-Sternberg cells (IHC, ×100).