Table 1.
HdhQ250 mice display selective brain atrophy
| Regions | WT (mm3) | HdhQ250 (mm3) |
|---|---|---|
| Whole brain | 436.0 ± 4.0 | 430.2 ± 1.5 |
| Accumbens Nu | 1.76 ± 0.01 | 1.64 ± 0.06 |
| Amygdala | 6.34 ± 0.12 | 6.46 ± 0.05 |
| Anterior commissure | 1.25 ± 0.02 | 1.18 ± 0.02 |
| Striatum | 19.18 ± 0.20 | 18.30 ± 0.03* |
| Corpus collasum | 13.30 ± 0.22 | 13.01 ± 0.05 |
| Cerebellum | 50.33 ± 0.92 | 53.34 ± 0.25 |
| Fimbria | 2.11 ± 0.06 | 2.25 ± 0.14 |
| Fornix | 0.08 ± 0.00 | 0.08 ± 0.00 |
| Hippocampus | 22.54 ± 0.29 | 23.07 ± 0.41 |
| Hypothalamus | 11.73 ± 0.20 | 11.97 ± 0.11 |
| Internal capsule | 4.86 ± 0.12 | 4.83 ± 0.02 |
| Lateral globus pallidus | 1.96 ± 0.04 | 1.91 ± 0.01 |
| Neocortex | 82.37 ± 0.80 | 78.16 ± 0.48* |
| Periform cortex | 2.79 ± 0.07 | 2.72 ± 0.02 |
| Thalamus | 18.68 ± 0.28 | 18.15 ± 0.12 |
| Lateral ventricle | 9.90 ± 0.68 | 11.89 ± 0.97 |
In vivo MRI quantification data in 15 different brain regions and lateral ventricle size in 6-month-old HdhQ250 mice and age-matched WT controls. Note the striatum and neocortex regions exhibit significant reduced volume while other regions have not shown difference in 6-month-old HdhQ250 mice. Data are mean ± SEM, n = 6
*P < 0.05 compared with the volume of age-matched WT control mice by standard Student's t-test.