Figure 2.

HAMAP annotation rule MF_01976 for mixed-substrate PFK group III family. The right hand panel shows snippets of the annotation rule MF_01976 including conditions used to specify site-specific annotations propagated to target sequences. If a protein sequence matches the HAMAP family profile MF_01976, then appropriate annotations for all members of that family (such as family membership) are attached to the sequence. For the annotation of sequence features, the target sequence is aligned to the seed alignment and the active site residue from the template sequence mapped to the target sequence. The nature of the residue at the equivalent position in the target sequence determines which of the possible conditional annotations will be attached to the sequence.