Table 2.
The summary of in vivo studies of chitin for wound healing.
| Preparation | Animal | Major results | Ref. |
|---|---|---|---|
| Chitin | Dog | Numbers of MN and PMN cells were larger in the chitin group than in the control group. Formation of granulating tissue around the implant was identified in the chitin group | [43] |
| Chitin-sponge | Dog, cow, cats, etc. | Chitin-sponges were applied in 30 cases as filling agents for surgical tissue defects, in 25 trauma cases, and in 31 cases of abscess as a wound dressing or tissue defect-filling agent. In 77 out of 86 cases (89.5%), good healing developed | [44] |
| Chitin-cotton | Dog, cow, cats, etc. | Chitin-cotton was applied in 8 cases of trauma and 12 cases of abscess as a wound dressing or tissue defect-filling agent. In 18 out of 20 cases (90.0%), good healing developed | [44] |
| Chitin-flake | Dog, cow, cats, etc. | Chitin-flake was applied in 9 cases of trauma as a wound dressing or tissue defect-filling agent. In 8 out of 9 cases (88.9%), good healing developed | [44] |
| Chitin/NWF | Dog | The amount of PGE2 in the exudate induced by chitin/NWF was about 5 times as high as that in the exudate induced by NWF | [45] |
| Chitin | Dog | Chitin activated the complement components C3 and C5, but not C4 | [46] |
| Chitin | Rat | Compared to chitosan, chitin at the higher concentration (10 mg/mL) induced stable collagen synthesis without scatter in the early wound-healing process | [47] |