Table 3.
The summary of in vitro studies of chitosan for wound healing.
| Preparation | Cells | Major results | Ref. |
|---|---|---|---|
| Chitosan | HaCaT | Chitosan exhibited a molecular weight-dependent negative effects on cell viability and proliferation | [49] |
| Chitosan | Fibroblast | Chitosan with high DDA strongly stimulated proliferation | [50] |
| Chitosan, their oligomer/monomer | 3T6 | The migratory activity was reduced by chitosan and GlcN | [37] |
| Chitosan, their oligomer/monomer | HUVECs | The migratory activity was enhanced by chitosan | [37] |
| Chitosan-based membranes | Human PMNs | PMNs, in the presence of chitosan, secrete lysozyme. The materials do not stimulate the production of ROS | [51] |
| Chitosan | Human PMNs | PMNs, stimulated with G-CSF and chitosan, accumulated osteopontin mRNA and released osteopontin | [52] |
| Chitosan | Macrophage | Chitosan had a stimulatory effect on both macrophage nitric oxide (NO) production and chemotaxis | [53] |