Table 2.
Patient-reported QOL Following Organ Sparing Chemo-IMRT
| Measure |
Pre-Treatment1 Mean (95% CI) |
24-month1 Mean (95% CI) |
Long-term1 Mean (95% CI) |
Δ long-term vs. 24 months2 Mean (95% CI) p |
Δ long-term vs. pre-treatment2 Mean (95% CI) p |
|---|---|---|---|---|---|
| HNQOL Instrument | |||||
| Summary Score | 15.1 (11.2 to 19.0) |
9.5 (6.3 to12.6) |
11.9 (6.9 to 16.9) |
+1.0 (−2.2 to 4.2) p=0.52 |
−3.2 (−8.1 to 1.7) p=0.20 |
| Eating | 9.4 (4.8 to 13.9) |
15.8 (10.7 to 20.9) |
15.5 (10.1 to 20.9) |
−1.4 (−5.3 to 2.4) p=0.44 |
+6.2 (0.1 to 12.3) p=0.05 |
| Pain | 17.3 (12.5 to 22.1) |
9.3 (5.0 to 13.6) |
15.2 (8.5 to 21.8) |
+5.1 (−0.9 to 11.1) p=0.09 |
−2.1 (−8.6 to 4.3) p=0.51 |
| Communication | 8.3 (3.9 to 12.7) |
4.6 (2.1 to 7.1) |
7.3 (2.8 to 11.9)) |
+1.3 (−2.4 to 5.0) p=0.48 |
−0.9 (−6.7 to 4.9) p=0.75 |
| Emotion | 21.3 (15.5 to 27.1) |
5.9 (2.4 to 9.3) |
8.5 (3.2 to 13.8) |
+1.2 (−2.4 to 4.9) p=0.49 |
−12.8 (−18.3 to −7.2) p<0.001 |
| Overall Bother | 32.1 (23.3 to 40.8) |
10.8 (5.6 to 16.0) |
16.3 (9.1 to 23.4) |
+4.2 (−0.7 to 9.0) p=0.09 |
−15.4 (−24.0 to −6.7) p<0.001 |
| UWQOL Instrument | |||||
| Summary Score | 10.0 (6.6 to 13.4) |
15.2 (11.3 to 19.0) |
16.5 (11.9 to 21.1) |
+0.5 (−2.4 to 3.4) p=0.72 |
+6.5 (1.6 to 11.4) p=0.01 |
| Swallowing | 6.3 (1.5 to 11.0) |
9.7 (5.1 to 14.4) |
13.1 (7.7 to 18.6) |
+2.1 (−2.1 to 6.3) p=0.49 |
+6.9 (−0.1 to 13.9) p=0.05 |
| XQ Summary Score | 6.4 (2.2 to 10.6) |
29.0 (20.4 to 37.7) |
29.9 (21.2 to 38.5) |
−0.8 (−5.7 to 4.1) p=0.74 |
+23.4 (14.8 to 32.1) p<0.001 |
1
includes all patients with responses at study time-point
2
includes only patients with responses at both time-points