Table 5.
Univariate Logistic Regression Analysis of Worsening Overall Bother From 24 Months to Long-Term Follow-up after Organ-Sparing Chemo-IMRT
| Variable | Odds ratio | 95% Confidence Interval | P |
|---|---|---|---|
| Age | 0.96 | 0.86 to 1.07 | 0.44 |
| T-classification | 2.62 | 1.01 to 6.79 | 0.048 |
| N-classification | 1.60 | 0.29 to 8.76 | 0.59 |
| Tumor Site (Base of Tongue vs. Tonsil) | 3.75 | 0.64 to 22.0 | 0.14 |
| Primary Tumor GTV (per ml) | 1.02 | 1.0 to 1.04 | 0.11 |
| Lymph Node GTV (per ml) | 1.02 | 0.99 to 1.05 | 0.25 |
| Smoking Pack-Years (per pack-year) | 0.95 | 0.88 to 1.02 | 0.18 |
| Post-CRT Neck Dissection (yes vs. no) | 12.50 | 1.69 to 92.3 | 0.023 |
| Months since CRT Completion (per month) | 1.06 | 1.01 to 1.11 | 0.021 |
| Total Pharyngeal Constrictor Mean Dose* | 6.12 | 1.47 to 25.5 | 0.013 |
| Superior Pharyngeal Constrictor Mean Dose* | 6.19 | 1.08 to 35.4 | 0.041 |
| Middle Pharyngeal Constrictor Mean Dose* | 4.03 | 1.11 to 14.6 | 0.034 |
| Inferior Pharyngeal Constrictor Mean Dose* | 2.95 | 1.23 to 7.16 | 0.016 |
| Cervical Esophagus Mean Dose* | 3.80 | 1.52 to 9.50 | 0.0044 |
| Supraglottic & Glottic Larynx Mean Dose* | 3.90 | 1.43 to 10.7 | 0.0079 |
| Oral Cavity Mean Dose* | 2.08 | 0.90 to 4.81 | 0.088 |
| Parotid Gland Mean Dose* | 1.66 | 0.76 to 3.60 | 0.20 |
| Submandibular Gland Mean Dose* | 7.58 | 1.29 to 44.6 | 0.025 |
| Baseline Overall Bother Domain Score^ | 1.01 | 0.98 to 1.04 | 0.52 |
CRT = chemoradiation; GTV = gross tumor volume.
*
Odds ratio calculated per 10 Gy increase in mean dose to each structure
^
Per point on 0–100 scale