Figure 2. Expression of IRAK-M regulates bleomycin induced pulmonary fibrosis.
WT and IRAK-M−/− mice were given an i.t challenge with bleomycin and whole lungs were isolated at either day 0, 14, or 21 and amount of collagen was assessed by hypdroxyproline assay (A), mRNA expression of collagen III in whole lungs (B) or trichrome staining of histological sections (C). Graphs represent mean ± SEM with n=4 samples/group from 2 separate experiments. *p<0.05, **p<0.01, ***p<0.001 when compared to day 0 WT control sample