Table 1. List of EGFR mutations in NSCLC resulting in sensitivity or resistance to first generation TKIs (21).

TKI sensitivity	Exon 18	Exon 19	Exon 20	Exon 21
Sensitive	G719C, G7119S, G7119A, V689M, N700D, E709K/Q, S720P	∆E746-A750, ∆E746-T751, ∆E746-A750 (ins RP), ∆E746-T751 (ins A/I), ∆E746-T751 (ins VA), ∆E746-S752 (ins A/V), ∆L747-E749 (A750P), ∆L747-A750 (ins P), ∆L747-T751, ∆L747-T751 (ins P/S), ∆L747-S752, ∆L747-752 (E746V), ∆L747-752 (P753S), ∆L747-S752 (ins Q), ∆L747-P753, ∆L747-P753 (ins S), ∆S752-I759	V765A, T783A	L858R, N826S, A839T, K846R, L861Q, G863D
Resistance		D761Y	D770_N771 (ins NPG), D770_N771 (ins SVQ), D770_N771 (ins G), N771T V769L, S768I, T790M

EGFR, epidermal growth factor receptor; NSCLC, non-small cell lung cancer; TKIs, tyrosine kinase inhibitors.