Table 2.

Summary of changes of all region perfusion responses by treatment and time under normal conditions

		Placebo			Ambrisentan
Measure	Change period	Change (95% CI)	Change P -value	Overall P -value	Change (95% CI)	Change P -value	Overall P -value
All	1 W - Base	0.18 (−0.27,0.63)	0.42	0.54	0.11 (−0.15,0.37)	0.41	0.61
	12 W - Base	−0.06 (−0.51,0.39)	0.80		−0.01 (−0.28,0.25)	0.93
	12 W - 1 W	−0.24 (−0.69,0.21)	0.29		−0.12 (−0.38,0.15)	0.37
R1	1 W - Base	0.23 (−0.18,0.64)	0.26	0.29	0.12 (−0.11,0.36)	0.29	0.30
	12 W - Base	−0.08 (−0.48,0.33)	0.71		−0.06 (−0.30,0.18)	0.62
	12 W - 1 W	−0.31 (−0.71,0.10)	0.14		−0.18 (−0.42,0.06)	0.13
R2	1 W - Base	0.15 (−0.32,0.62)	0.52	0.76	0.03 (−0.24,0.31)	0.80	0.80
	12 W - Base	0.00 (−0.47,0.47)	0.99		−0.06 (−0.34,0.22)	0.68
	12 W - 1 W	−0.15 (−0.62,0.32)	0.53		−0.09 (−0.37,0.19)	0.51
R3	1 W - Base	0.08 (−0.42,0.57)	0.76	0.79	0.12 (−0.17,0.40)	0.40	0.70
	12 W - Base	−0.09 (−0.59,0.40)	0.71		0.05 (−0.24,0.34)	0.71
	12 W - 1 W	−0.17 (−0.66,0.33)	0.50		−0.07 (−0.36,0.23)	0.65
R4	1 W - Base	0.27 (−0.26,0.80)	0.31	0.42	0.15 (−0.16,0.45)	0.33	0.57
	12 W - Base	−0.06 (−0.59,0.47)	0.81		0.02 (−0.30,0.33)	0.91
	12 W - 1 W	−0.33 (−0.86,0.20)	0.22		−0.13 (−0.45,0.18)	0.40
Worst	1 W - Base	0.18 (−0.20,0.56)	0.35	0.45	0.18 (−0.04,0.40)	0.10	0.25
	12 W - Base	−0.05 (−0.43,0.33)	0.79		0.06 (−0.16,0.29)	0.57
	12 W - 1 W	−0.23 (−0.61,0.15)	0.23		−0.12 (−0.34,0.11)	0.29

The ROIs are mentioned as R1 to R4 along with the area of worst perfusion, measured over the study duration. P-values are from repeated measure analysis of variance models. Base = baseline; W = week; Worst = worst perfusion. CI, confidence interval; ROI, region of interest.