Figure 1.

A schematic diagram for effect of promoter leakage on expression dynamics. (A) schematic description of two-state gene auto-regulatory model with leakage, where gene product is produced not only at the ON state with high efficiency but also at the OFF state with very low efficiency (termed as promoter leakage); (B) representative time series for changes in the number of gene products (left) and effect of leakage on population distribution (right).